Home search: research article platelet antibodies of the igm class in immune thrombocytopenic purpura. D b cines, s b wilson, a tomaski and a d schreiber publication information published in volume 75, issue 4 (april 1985) j clin invest.
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1985;75(4):1183â€“1190. Doi:10. viagra prescription young men 1172/jci111814. viagra v viagra questions Copyright â© 1985, the american society for clinical investigation. indian viagra women Published april 1985 abstract the clinical course and response to therapy of patients with immune thrombocytopenic purpura (itp) are not completely determined by the level of igg present on the platelet surface. wo kann man viagra online bestellen It is possible that antibodies of other immunoglobulin classes also play a role in platelet destruction in some of these patients. Therefore, we studied clxxv patients with itp for the presence of igm anti-platelet antibodies using radiolabeled polyclonal or monoclonal anti-igm. natural products work like viagra We observed that 57% of patients with clinical itp had increased levels of igm on their platelets, compared with normal controls and patients with thrombocytopenia who did not have itp (less than 10%), (p less than 0. indian viagra women 01). We obtained similar results using either radiolabeled polyclonal or monoclonal anti-igm, reagents whose integrity was first characterized using erythrocytes coated with defined amounts of igm antibody.
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Among patients with increased platelet-igm there was a significant correlation both with the presence of increased platelet-c3 as well as the amount of platelet-c3 (p less than 0.
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01, r = 0.
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We demonstrated the presence of warm-reacting igm anti-platelet antibodies in the plasma of two of these patients who were further studied.
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The isolated igm fraction from these two plasmas was able to activate complement and place 3h-c3 on normal platelets. how long will 100mg of viagra last These studies demonstrate the presence of warm-reacting igm anti-platelet antibodies in some patients with itp.
They suggest that the binding of complement to platelets by igm antibodies may initiate platelet clearance as well as enhance the effect of igg antibodies in itp. Browse pages click on an image below to see the page. indian viagra women View pdf of the complete article page 1183 page 1184 page 1185 page 1186 page 1187 page 1188 page 1189 page 1190 view full site facebook twitter. Lood clot by clumping together to plug small holes in damaged blood vessels.
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The antibodies attach to the platelets.
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The spleen destroys the platelets that carry the antibodies. viagra 10 mg daily In children, the disease sometimes follows a viral infection. In adults, it is more often a chronic (long-term) disease and can occur after a viral infection, with use of certain drugs, during pregnancy, or as part of an immune disorder.
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Itp affects women more frequently than men, and is more common in children than adults.
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The disease affects boys and girls equally. Symptoms abnormally heavy menstruation bleeding into the skin causes a characteristic skin rash th.
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